A PHASE 2 STUDY OF COMBINED CHEMO-IMMUNOTHERAPY WITH CISPLATIN-PEMBROLIZUMAB AND RADIATION FOR UNRESECTABLE VULVAR SQUAMOUS CELL CARCINOMA

A phase 2 study of combined chemo-immunotherapy with cisplatin-pembrolizumab and radiation for unresectable vulvar squamous cell carcinoma

Abstract Background Unresectable or metastatic vulvar cancer has relatively poor outcomes despite chemotherapy-sensitized radiation therapy and combination cytotoxic therapy.Despite the virus-associated and immunogenic nature of this disease, novel immunotherapy options that exploit this advantage are currently lacking.Platinum agents such as cispl

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CONCEPT OF AUTONOMOUS TEXTILE FOIL KITE - WIND ENERGY GENERATOR

This paper presents the starting phase of a research project that aims to develop the technological demonstrator of a wind power generator system using a wind sail to capture the high altitude wind energy.The sail will capture the wind energy and will be raised to an altitude of minimum 100-200 meters to capture the stronger and more constant winds

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Global Lipidome Profiling Revealed Multifaceted Role of Lipid Species in Hepatitis C Virus Replication, Assembly, and Host Antiviral Response

Hepatitis C virus (HCV) is a major human pathogen that requires a better understanding of its interaction with host cells.There is a close association of HCV life cycle with host lipid metabolism.Lipid droplets (LDs) have been found to be crucial organelles that support HCV replication and virion assembly.In addition to their role in replication, L

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